Comparison of two different antibiotic regimens for the prophylaxisis of cases with preterm premature rupture of membranes: a randomized clinical trial

Objectives: The aim of the study was to assess the effect of 1 g ampicillin prophylactic dosage whether it is as effective as the dosage of 2 g to prevent maternal and neonatal morbidity in a randomized manner. Materials and methods: One hundred and fourty eight singleton pregnant women with preterm premature rupture of membranes between 21 and 33 weeks of gestation were followed-up during the study period in our institution. We com­pared the efficacy of two different different dosages of ampicillin. The study population was randomized into 2 groups. In the group 1, 1 g of intravenous ampicillin was given every 6 hours. In the group 2, 2 g of intravenous ampicillin was given every 6 hours. Results: There was no significant difference between groups interms of fetal complications (RDS, icterus, mortality, sepsis, transient tachypnea of newborn and the pneumonia), rate of intensive care unit admission, fetal gender, fever, rate of clinical chorioamnionitis, high white blood cell count and the CRP, rate of cases < 30 weeks (p > 0.05). There was a significant differ­ence between the groups for the rate of previous preterm premature rupture of membranes history, steroid administration and the need for tocolysis (p < 0.05). Conclusions: Although antibiotics seems to be innocent, several side effects have been introduced. It is reasonable to use the lowest dosages in shortest period in order to minimize these unwanted effects

Solvent effects on UV-Vis and FT-IR spectra of indapamide combined with DFT calculations

The present study aimed to analyze the solute-solvent interactions of indapamide using FT-IR, UV-Vis spectroscopies in combination with DFT calculations in four different solvents. The FT-IR spectra of indapamide and solutions of indapamide prepared in ethanol, in methanol, in THF and in DMSO were recorded. The theoretical analysis of probable stable conformers of indapamide was carried out using DFT/B3LYP functional with 6-31G (d,p), 6-311 G ++ (d,p) and plus D3 empirical dispersion function with 6-311 ++G(d,p) basis sets in different media. The optimized geometry and vibrational wavenumbers of indapamide were calculated using DFT method at the same level. Solvent effects of indapamide were performed with conductor-like polarizable continuum model (CPCM) method. The electronic absorption spectra of the molecule were estimated by the time-dependent DFT method at the same level. Solute-solvent interactions are investigated by means of the multi-component linear regression analysis of Kamlet-Taft parameters. Also in this study, the solvent-accessible surface area (SASA) and HOMO-LUMO energy gap were calculated using the quantum chemical calculations

Comorbidity of Adult Attention Deficit and Hyperactivity Disorder in Bipolar Patients: Prevalence, Sociodemographic and Clinical Correlates

Introduction: The aims of this study were to determine the frequency of adult attention deficit and hyperactivity disorder (ADHD) comorbidity in bipolar patients and to investigate the influence of this comorbidity on the clinical characteristics of bipolar disorder (BD)

Experimental and theoretical studies on cis-dioxomolybdenum(VI) complexes of ONN-donor thiosemicarbazon

Cis-dioxomolybdenum(VI) chelate complexes with 5-chloro-2-hydroxybenzophenone S-methy1-4-phenylthiose-micarbazone (L) were synthesized in the general formula (MoO2 (L)D), where D is an odd- or even-numbered alcohol (methanol (1), ethanol (2), n-propanol (3), n-butanol (4), and allyl alcohol (5)). The structures of 1-5 were verified by elemental analysis, Fourier transform infrared (FT-IR), and H-1 NMR spectra. Complex 5 crystallizes in the monoclinic space group P21/n, and its crystalline data showed a dimeric structure formed by a pair of intermolecular hydrogen bonds with 1.92. These dimers are stacked in a similar crystalline structure as a single molecule. The experimental data were compared with the theoretical results obtained by the quantum chemical calculations of the DFT/B3LYP method with LANL2DZ basis set. A detailed interpretation of the FT-IR spectra of the studied compounds was performed based on the total energy distribution. In order to investigate the electronic structures and the UV-Vis spectrum of complex 5, time-dependent density functional theory calculation was taken into account. The interaction energies between the odd- and even-numbered alcohols and remaining parts of complexes 1-4 were evaluated with the help of natural bonding orbital analysis. In addition, the basis set superposition error correction energies were calculated. The results were evaluated by considering the coordinated alcohols with an even number of carbon atoms to have much higher interaction energy than the next lower homologous alcohols with an odd number of carbon atoms